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Rossoe
Site Admin Joined: 05 Feb 2006 Posts: 301 Location: Devon, UK	Posted: Wed Feb 27, 2013 11:12 am    Post subject: Fibulin-5 Protein reduced in the Lung of patients with SP's   An interesting Japanese study from 2012 aiming to clarify whether fibulin-5 is associated with primary spontaneous pneumothorax (PSP) in young PSP patients. Quote: A high incidence of pneumothorax is a relatively common problem in Japan. PSP commonly occurs in young, thin males. PSP has an incidence of 7.4-8 cases (age-adjusted incidence) and 1.2-6 cases/100000 population per year in males and females, respectively. Fibulin-5 contributes to the formation of elastic fibers by binding to structural components including tropoelastin and fibrillin-1. Studies in fibulin-5 deficient mice have shown that fibulin-5 is necessary for the biosynthesis of elastic fibers. Conclusions: We showed that fibulin-5 is reduced in patients with PSP who are younger than 25 years. Download study - pdf
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