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Fibulin-5 Protein reduced in the Lung of patients with SP's

 
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PostPosted: Wed Feb 27, 2013 11:12 am    Post subject: Fibulin-5 Protein reduced in the Lung of patients with SP's
 
An interesting Japanese study from 2012 aiming to clarify whether fibulin-5 is associated with primary spontaneous pneumothorax (PSP) in young PSP patients.

Quote:
A high incidence of pneumothorax is a relatively common problem in Japan.

PSP commonly occurs in young, thin males. PSP has an incidence of 7.4-8 cases (age-adjusted incidence) and 1.2-6 cases/100000 population per year in males and females, respectively.

Fibulin-5 contributes to the formation of elastic fibers by binding to structural components including tropoelastin and fibrillin-1. Studies in fibulin-5 deficient mice have shown that fibulin-5 is necessary for the biosynthesis of elastic fibers.

Conclusions: We showed that fibulin-5 is reduced in patients with PSP who are younger than 25 years.


Download study - pdf




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